Effects of Porphyromonas gingivalis and Fusobacterium nucleatum on inflammasomes and their regulators in H400 cells.,Molecular Oral Microbiology

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Effects of Porphyromonas gingivalis and Fusobacterium nucleatum on inflammasomes and their regulators in H400 cells.
Molecular Oral Microbiology ( IF 2.8 ) Pub Date : 2020-06-26 , DOI: 10.1111/omi.12302
Kübra Aral _{1,

2} , Michael R Milward ₃ , Dhanak Gupta ₁ , Paul R Cooper _{3,

4}

Affiliation

Inflammasomes are multiprotein complexes that regulate immune processes in response to infections and tissue damage. They modulate Interleukin‐1beta (IL‐1β) expression, a major proinflammatory cytokine. The inflammasome/IL‐1β pathway is involved in head and neck squamous cell carcinoma (HNSCC) progression and the periodontal pathogens Fusobacterium nucleatum (Fn) and Porphyromonas gingivalis (Pg) have been reported to cause chronic inflammation in HNSCC. The aim of this study was to characterise the role of these pathogens in regulating inflammasome activity and the IL‐1β response in HNSCC in vitro.

中文翻译：

牙龈卟啉单胞菌和核梭菌对H400细胞中的炎性体及其调节剂的影响。

炎症小体是多蛋白复合物，可调节免疫过程以应对感染和组织损伤。它们调节白介素-1β（IL-1β）的表达，这是一种主要的促炎细胞因子。炎性小体/IL-1β途径与头颈部鳞状细胞癌（HNSCC）的进展有关，据报道牙周病原体是核梭状芽孢杆菌（Fn）和牙龈卟啉单胞菌（Pg）会引起HNSCC的慢性炎症。这项研究的目的是表征这些病原体在体外调节HNSCC中炎症小体活性和IL-1β反应中的作用。

更新日期：2020-06-26

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