Trehalose against Alzheimer's Disease: Insights into a Potential Therapy.,BioEssays

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Trehalose against Alzheimer's Disease: Insights into a Potential Therapy.
BioEssays ( IF 3.2 ) Pub Date : 2020-06-09 , DOI: 10.1002/bies.201900195
Masoomeh Khalifeh ₁ , Morgayn I Read ₂ , George E Barreto _{3,

4} , Amirhossein Sahebkar _{5,

6,

7}

Affiliation

Trehalose is a natural disaccharide with a remarkable ability to stabilize biomolecules. In recent years, trehalose has received growing attention as a neuroprotective molecule and has been tested in experimental models for different neurodegenerative diseases. Although the underlying neuroprotective mechanism of trehalose's action is unclear, one of the most important hypotheses is autophagy induction. The chaperone‐like activity of trehalose and the ability to modulate inflammatory responses has also been reported. There is compelling evidence that the dysfunction of autophagy and aggregation of misfolded proteins contribute to the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. Therefore, given the linking between trehalose and autophagy induction, it appears to be a promising therapy for AD. Herein, the published studies concerning the use of trehalose as a potential therapy for AD are summarized, providing a rationale for applying trehalose to reduce Alzheimer's pathology.

中文翻译：

海藻糖对抗阿尔茨海默病：对潜在疗法的洞察。

海藻糖是一种天然二糖，具有显着的稳定生物分子的能力。近年来，海藻糖作为一种神经保护分子受到越来越多的关注，并已在不同神经退行性疾病的实验模型中进行了测试。尽管海藻糖作用的潜在神经保护机制尚不清楚，但最重要的假设之一是自噬诱导。海藻糖的分子伴侣样活性和调节炎症反应的能力也有报道。有令人信服的证据表明，自噬功能障碍和错误折叠蛋白的聚集导致阿尔茨海默病 (AD) 和其他神经退行性疾病的发病机制。因此，考虑到海藻糖和自噬诱导之间的联系，它似乎是一种很有前途的 AD 疗法。在此处，

更新日期：2020-07-29

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