Maneuvering the Migration and Differentiation of Stem Cells with Electrospun Nanofibers.,Advanced Science

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Maneuvering the Migration and Differentiation of Stem Cells with Electrospun Nanofibers.
Advanced Science ( IF 14.3 ) Pub Date : 2020-06-09 , DOI: 10.1002/advs.202000735
Jiajia Xue ₁ , Dario Pisignano _{2,

3} , Younan Xia _{1,

4}

Affiliation

Electrospun nanofibers have been extensively explored as a class of scaffolding materials for tissue regeneration, because of their unique capability to mimic some features and functions of the extracellular matrix, including the fibrous morphology and mechanical properties, and to a certain extent the chemical/biological cues. This work reviews recent progress in applying electrospun nanofibers to direct the migration of stem cells and control their differentiation into specific phenotypes. First, the physicochemical properties that make electrospun nanofibers well‐suited as a supporting material to expand stem cells by controlling their migration and differentiation are introduced. Then various systems are analyzed in conjunction with mesenchymal, neuronal, and embryonic stem cells, as well as induced pluripotent stem cells. Finally, some perspectives on the challenges and future opportunities in combining electrospun nanofibers with stem cells are offered to address clinical issues.

中文翻译：

用电纺纳米纤维操纵干细胞的迁移和分化。

电纺纳米纤维作为一类用于组织再生的支架材料已被广泛探索，因为它们具有模仿细胞外基质的一些特征和功能的独特能力，包括纤维形态和机械性能，以及在一定程度上的化学/生物线索。这项工作回顾了应用电纺纳米纤维引导干细胞迁移并控制其分化为特定表型的最新进展。首先，介绍了电纺纳米纤维的物理化学特性，这些特性使电纺纳米纤维非常适合作为支持材料，通过控制干细胞的迁移和分化来扩增干细胞。然后结合间充质、神经元和胚胎干细胞以及诱导多能干细胞对各种系统进行分析。最后，对电纺纳米纤维与干细胞结合所面临的挑战和未来机遇提出了一些观点，以解决临床问题。

更新日期：2020-08-05

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