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Therapeutic Resevoirs: Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models (Adv. Healthcare Mater. 11/2020)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-06-10 , DOI: 10.1002/adhm.202070035
Garry P. Duffy , Scott T. Robinson , Raymond O'Connor , Robert Wylie , Ciaran Mauerhofer , Gabriella Bellavia , Stefania Straino , Francesca Cianfarani , Keegan Mendez , Rachel Beatty , Ruth Levey , Janice O'Sullivan , Liam McDonough , Helena Kelly , Ellen T. Roche , Eimear B. Dolan

In article number 2000305 by Ellen T. Roche, Eimear B. Dolan, and co‐workers, a new regenerative reservoir platform (Regenervoir) is described for use in large animal models that are easily translated to human studies, with relevance to cardiac, abdominal, and soft tissue pathologies. Regenervoir incorporates multiple novel design features essential for clinical translation, with a focus on scalability, mechanism of delivery, fixation, and filling/refilling with a therapeutic cargo.
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中文翻译:

治疗性储库:用于大型动物模型中多种临床应用的可植入治疗储库系统(Adv。Healthcare Mater。11/2020)

在Ellen T. Roche,Eimear B. Dolan及其同事的文章编号2000305中,描述了一种新的蓄水池平台(Regenervoir),该平台可用于大型动物模型,这些模型易于转化为人体研究,与心脏,腹部相关和软组织病理。Regenervoir融合了临床翻译必不可少的多种新颖设计功能,重点在于可扩展性,递送机制,固定方式以及用治疗性货物填充/重新填充。
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更新日期:2020-06-10
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