Due to the cellular entry of the novel coronavirus (SARS-CoV-2) modulated by angiotensin converting enzyme 2 (ACE2), the ACE2 bearing prostate is therefore hypothesized as a susceptible organ to COVID-19. To delineate whether the pathogenic SARS-CoV-2 of the coronavirus disease (COVID-19) could be detected in the expressed prostatic secretion (EPS), a total of ten male patients with confirmed COVID-19 were recruited. All patients were stratified into two groups: one group with positive nasopharyngeal swabbing SARS-CoV-2 within 3 days of the EPS taken day (PNS group, n = 3) and the other group with previously positive nasopharyngeal swabbing SARS-CoV-2 but turned negative before the taken day (PNNS group, n = 7). The COVID-19 patients showed elevated inflammatory indictors, i.e. C-reaction protein (3.28 (1.14, 33.33) mg/L), erythrocyte sedimentation rate (22.50 (8.00, 78.50) mm/h), and interleukin-6 (6.49 (4.96, 21.09) pg/ml). Serum IgM against SARS-CoV-2 was only positive in the PNS group, whereas serum IgG was positive for all patients. Furthermore, our data showed for the first time that none of the COVID-19 patients had positive SARS-CoV-2 RNA in EPS. To this end, this study found the negativity of SARS-CoV-2 in EPS and possibly exclude the sexual transmission of COVID-19.

由于血管紧张素转换酶 2 (ACE2) 调节的新型冠状病毒 (SARS-CoV-2) 进入细胞，因此假设带有 ACE2 的前列腺是 COVID-19 的易感器官。为了确定是否可以在表达的前列腺分泌物（EPS）中检测到冠状病毒病（COVID-19）的致病性 SARS-CoV-2，总共招募了 10 名确诊为 COVID-19 的男性患者。所有患者被分为两组：一组在 EPS 采集日 3 天内鼻咽拭子 SARS-CoV-2 呈阳性（PNS 组，n = 3），另一组之前鼻咽拭子 SARS-CoV-2 呈阳性，但在服用当天之前转为阴性（PNNS 组，n = 7）。COVID-19患者的炎症指标升高，即C反应蛋白（3.28（1.14，33.33）mg/L）、红细胞沉降率（22.50（8.00，78.50）mm/h）和白细胞介素6（6.49（4.96） ，21.09) 皮克/毫升)。仅 PNS 组的血清 SARS-CoV-2 IgM 呈阳性，而所有患者的血清 IgG 均呈阳性。此外，我们的数据首次显示，没有一名 COVID-19 患者 EPS 中 SARS-CoV-2 RNA 呈阳性。为此，本研究发现EPS中SARS-CoV-2呈阴性，并可能排除COVID-19的性传播。