In this issue of Cell Host & Microbe, Jia et al. used a vesicular stomatitis virus-based probe to isolate B cells expressing broadly neutralizing HIV-1 antibodies. Besides identifying neutralizing epitopes, this study highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or sequential IgM-to-IgG-to-IgA class switching.

中文翻译：

---

IgA召集IgG击中HIV-1。

在本期《细胞宿主与微生物》杂志上，贾等人。使用基于水泡性口炎病毒的探针分离表达广泛中和的HIV-1抗体的B细胞。除了鉴定中和表位外，这项研究还强调了由直接IgM到IgA或顺序IgM到IgG到IgA类别转换产生的IgA提供的潜在保护。