We highlight a recent paper which documents the important role that Ca²⁺ release through type-1 Inositol 1,4,5-trisphosphate receptor (IP₃R1) plays in the acute regulation by glucagon of gluconeogenesis in hepatocytes. The specificity is likely the result of discrete localization close to mitochondria and PKA-dependent phosphorylation of IP₃R1 which enhances Ca²⁺ release.

中文翻译：

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1 型肌醇 1,4,5-三磷酸受体对胰高血糖素诱导的糖异生的关键作用。

我们重点介绍了最近的一篇论文，该论文记录了通过 1 型肌醇 1,4,5-三磷酸受体 (IP ₃ R1)释放的Ca ²⁺在胰高血糖素对肝细胞糖异生的急性调节中发挥的重要作用。特异性可能是靠近线粒体的离散定位和 IP ₃ R1 的PKA 依赖性磷酸化的结果，这增强了 Ca ^{2+ 的}释放。