Transient Receptor Potential Vanilloid 1 (TRPV1) channels are non-selective cationic polymodal receptors gated by several different chemical and physical stimuli. TRPV1 receptors are distributed in several brain areas and interact with important neurotransmitter systems linked to mental disorders, such as endocannabinoid and opioid systems. The increasing number of results obtained in this field has recently attracted growing attention to these receptors as potential targets for the treatment of different psychiatric conditions. To review the available results on this topic, we searched on PubMed, Embase and Science Direct databases up to May 2020 using the following search string: “TRPV1”, thus including a total of 48 studies. The results, still limited to preclinical studies, suggest that TRPV1 antagonism could represent a potential mechanism for the treatment of depression and anxiety, as well as for opioids, methamphetamine and cocaine addiction. Few available results consider schizophrenia-like behaviours, suggesting an intriguing role of TRPV1 receptors in the neurobiology of major psychoses. Single studies report the effectiveness of TRPV1 antagonists in animal models of obsessive-compulsive disorder and fibromyalgia. Future preclinical and clinical studies are required to shed further light on the feasibility of the use of TRPV1 modulators in psychopharmacology.

瞬态受体电位香草素 1 (TRPV1) 通道是由几种不同的化学和物理刺激门控的非选择性阳离子多峰受体。TRPV1 受体分布在多个大脑区域，并与与精神障碍相关的重要神经递质系统相互作用，例如内源性大麻素和阿片类物质系统。最近在该领域获得的结果越来越多，这些受体作为治疗不同精神疾病的潜在靶点引起了越来越多的关注。为了查看有关该主题的可用结果，我们使用以下搜索字符串在 PubMed、Embase 和 Science Direct 数据库中搜索了截至 2020 年 5 月的内容：“TRPV1”，因此总共包括 48 项研究。结果，仍然仅限于临床前研究，表明 TRPV1 拮抗作用可能代表治疗抑郁症和焦虑症以及阿片类药物、甲基苯丙胺和可卡因成瘾的潜在机制。很少有可用结果考虑精神分裂症样行为，这表明 TRPV1 受体在主要精神病的神经生物学中具有有趣的作用。单项研究报告了 TRPV1 拮抗剂在强迫症和纤维肌痛动物模型中的有效性。未来的临床前和临床研究需要进一步阐明在精神药理学中使用 TRPV1 调节剂的可行性。单项研究报告了 TRPV1 拮抗剂在强迫症和纤维肌痛动物模型中的有效性。未来的临床前和临床研究需要进一步阐明在精神药理学中使用 TRPV1 调节剂的可行性。单项研究报告了 TRPV1 拮抗剂在强迫症和纤维肌痛动物模型中的有效性。未来的临床前和临床研究需要进一步阐明在精神药理学中使用 TRPV1 调节剂的可行性。