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Molecular basis of macrolide-lincosamide-streptogramin (MLS) resistance in Finegoldia magna clinical isolates.
Anaerobe ( IF 2.5 ) Pub Date : 2020-06-10 , DOI: 10.1016/j.anaerobe.2020.102220
François Guérin 1 , Sabrine Lachaal 2 , Michel Auzou 1 , Cécile Le Brun 3 , Olivier Barraud 4 , Jean-Winoc Decousser 5 , Reto Lienhard 6 , Régine Baraduc 7 , Luc Dubreuil 8 , Vincent Cattoir 9
Affiliation  

Of 69 clinical isolates of Finegoldia magna tested, 36% presented high-level MICs of erythromycin (>256 μg/ml), harboring erm(A) (n = 20) or erm(B) (n=5). Of nine isolates exhibiting an inducible resistance phenotype to macrolides-lincosamides-streptogramins B, four (44%) were susceptible with a potential risk of treatment failure due to emergence of resistant mutants.



中文翻译:

巨大型Finegoldia magna临床分离物中大环内酯-林可酰胺-链霉菌素(MLS)抗性的分子基础。

在测试的69个Finegoldia magna临床分离株中,有36%表现出高红霉素(> 256μg/ ml),带有erm(A)(n = 20)或erm(B)(n = 5)。在对大环内酯类-林可酰胺类-链霉菌素B表现出可诱导的耐药表型的9个分离株中,有4个(44%)由于耐药突变体的出现而具有治疗失败的潜在风险。

更新日期:2020-06-10
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