Topics in Current Chemistry ( IF 8.6 ) Pub Date : 2020-06-10 , DOI: 10.1007/s41061-020-00303-9 Zhihui Xu 1 , Xiaogang Yang 1 , Shuang-Feng Yin 1 , Renhua Qiu 1
8-Aminoquinoline is a common nitrogen-containing heterocyclic framework in many natural products, functional materials and useful drugs. It has been developed as a powerful bidentate directing group or ligand auxiliary in the field of C–H bond activation/functionalization in recent years. In this context, the synthesis of substituted 8-aminoquinoline is of great importance. In this review we focus on the functionalization of positions C2–C7 on the 8-aminoquinoline ring, which involves the formation of C–C and C–Z (Z = heteroatom) bonds by transition metal catalysts, photocatalysts or metal-free conditions. Mechanistically, a single electron transfer (SET) pathway is suggested in most cases.
中文翻译:
8-氨基喹啉环的远程CH功能化。
8-氨基喹啉是许多天然产物,功能材料和有用药物中常见的含氮杂环骨架。近年来,它已被开发为C–H键激活/功能化领域中强大的双齿引导基团或配体辅助剂。在这种情况下,取代的8-氨基喹啉的合成非常重要。在这篇综述中,我们着眼于8-氨基喹啉环上C2-C7位的功能化,这涉及通过过渡金属催化剂,光催化剂或无金属条件形成C-C和C-Z(Z =杂原子)键。从机理上讲,大多数情况下建议采用单电子转移(SET)途径。