In current research, benzazepine derivative is synthesized via a new process of four-component reaction of isatin or its derivatives, α-haloketones, activated acetylenic compounds, isoquinoline and potassium fluoride/clinoptilolite nanoparticles (KF/CP NPs) in acidic solution of H₂O₂ in water at room temperature. Also, antioxidation property of some prepared benzazepines is investigated by employing trapping diphenyl-picrylhydrazine (DPPH) radical and ability of ferric reduction experiment. Among investigated compounds, compounds 5c have good results relative to BHT and TBHQ as standard antioxidant. Also, the Gram-positive and Gram-negative bacteria disk diffusion research is used for the confirmation of antimicrobial power of some prepared benzazepines. The achieved outcomes of disk diffusion experiment showed that these compounds avoided the growth of bacteria. Our procedure has a few benefits relative to reported method such as good rate of reaction, product with high efficiency, simple removal of catalyst from mixture of reaction. In the yield of the product, KF/clinoptilolite nanoparticles show a satisfactory recyclable activity.

目前研究采用靛红或其衍生物、α-卤代酮、活化炔属化合物、异喹啉和氟化钾/斜发沸石纳米颗粒(KF/CP NPs)在酸性H ₂溶液中进行四组分反应新工艺合成苯并氮杂衍生物。室温下，O ₂溶于水中。此外，通过捕获二苯基三硝基苯肼（DPPH）自由基和铁还原实验的能力，研究了一些制备的苯并氮杂卓的抗氧化性能。在研究的化合物中，化合物5c相对于作为标准抗氧化剂的 BHT 和 TBHQ 具有良好的结果。此外，革兰氏阳性和革兰氏阴性细菌纸片扩散研究用于确认一些制备的苯并氮杂卓的抗菌能力。纸片扩散实验所取得的结果表明这些化合物避免了细菌的生长。相对于报道的方法，我们的程序有一些优点，例如反应速率好、产物效率高、从反应混合物中简单地去除催化剂。在产品收率方面，KF/斜发沸石纳米粒子表现出令人满意的可回收活性。