The immune system plays a pivotal role in maintaining the defense mechanism against external agents and also internal danger signals. Metabolic programming of immune cells is required for functioning of different subsets of immune cells under different physiological conditions. The field of immunometabolism has gained ground because of its immense importance in coordination and balance of immune responses. Metabolism is very much related with production of energy and certain by-products. Reactive oxygen species (ROS) are generated as one of the by-products of various metabolic pathways. The amount, localization of ROS and redox status determine transcription of genes, and also influences the metabolism of immune cells. This review discusses ROS, metabolism of immune cells at different cellular conditions and sheds some light on how ROS might regulate immunometabolism.

免疫系统在维持防御外部因素和内部危险信号的防御机制中起着关键作用。在不同的生理条件下，免疫细胞的新陈代谢程序是免疫细胞的不同亚群发挥功能所必需的。免疫代谢领域由于其在协调和平衡免疫应答中的重要性而获得了发展。代谢与能量产生和某些副产物有很大关系。活性氧（ROS）是各种代谢途径的副产物之一。ROS的数量，位置和氧化还原状态决定了基因的转录，也影响了免疫细胞的代谢。这篇评论讨论了ROS，