During the rapidly developing and sensitive period of the central nervous system (CNS), a harmful stimulus may have serious consequences. The effect of anesthetic exposure on the development of the offspring’s CNS during pregnancy is still unclear and has been widely concerned. In the present study, we compared the susceptibility of the hippocampus with those of other brain regions in offsprings when the mother mice were exposed to repeated sevoflurane. We found that other than affecting motor sensation, emotion, or social behavior of offspring mice, repeated sevoflurane exposure induced significant memory deficiency. Compared with other brain regions, the hippocampus, which is the key component of the brain serving for learning and memory, was more vulnerable to repeated sevoflurane exposure. We also found that repeated sevoflurane exposure to mother mice could inhibit the axon development of hippocampal neurons. We also predicted that N6-methyladenosine modification of mRNA might play an essential role in the vulnerability of the hippocampus to sevoflurane, while the underlying cellular mechanism needs to be explored in the future. Our study may provide a new perspective for studying the mechanism of hippocampus-specific injury induced by sevoflurane exposure.

中文翻译：

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与其他大脑区域相比，在孕中期反复暴露于七氟醚会引起海马神经损伤。

在中枢神经系统（CNS）迅速发展和敏感的时期，有害的刺激可能会产生严重的后果。麻醉期间暴露于麻醉剂对后代中枢神经系统发育的影响仍不清楚，并已引起广泛关注。在本研究中，当母鼠反复暴露于七氟醚中时，我们比较了后代海马体与其他大脑区域的敏感性。我们发现，除了影响后代小鼠的运动感觉，情感或社交行为外，反复接触七氟醚还会引起明显的记忆缺陷。与其他大脑区域相比，海马作为大脑学习和记忆的关键组成部分，更容易受到七氟醚的反复暴露。我们还发现母鼠反复接触七氟醚可能会抑制海马神经元的轴突发育。我们还预测，mRNA的N6-甲基腺苷修饰可能在海马对七氟醚的脆弱性中起重要作用，而潜在的细胞机制需要在未来进行探索。我们的研究可能为研究七氟醚暴露引起的海马特异性损伤的机制提供新的观点。