Oxidative stress is a key factor that influences piglets’ health. Taurine plays an imperative role in keeping the biological system from damage. This study was conducted to investigate the protective effect of taurine against muscle injury due to the secondary effect of diquat toxicity. Our study found that taurine effectively and dose-dependently alleviated the diquat toxicity induced rise of feed/gain, with a concurrent improvement of carcass lean percentage. The plasma content of taurine was considerably increased in a dose-dependent manner. Consequently, dietary taurine efficiently improved the activity of plasma antioxidant enzymes. Furthermore, taurine attenuated muscle damage by restoring mitochondrial micromorphology, suppressing protein degradation and reducing the percentage of apoptotic cells in the skeletal muscle. Taurine supplementation also suppressed the genes expression levels of the antioxidant-, mitochondrial biogenesis-, and muscle atrophy-related genes in the skeletal muscle of piglets with oxidative stress. These results showed that the dose of 0.60% taurine supplementation in the diet could attenuate skeletal muscle injury induced by diquat toxicity. It is suggested that taurine could be a potential nutritional intervention strategy to improve growth performance.

中文翻译：

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牛磺酸对敌草快所致35天断奶仔猪肌肉损伤的保护作用。

氧化应激是影响仔猪健康的关键因素。牛磺酸在保护生物系统免受损害方面起着至关重要的作用。本研究旨在调查牛磺酸对敌草快毒性的继发性肌肉损伤的保护作用。我们的研究发现，牛磺酸有效且剂量依赖性地减轻敌草快毒性引起的饲料/增重增加，同时改善胴体瘦肉百分比。牛磺酸的血浆含量以剂量依赖性方式显着增加。因此，膳食牛磺酸有效地提高了血浆抗氧化酶的活性。此外，牛磺酸通过恢复线粒体微形态、抑制蛋白质降解和降低骨骼肌中凋亡细胞的百分比来减轻肌肉损伤。牛磺酸补充剂还抑制了氧化应激仔猪骨骼肌中抗氧化剂、线粒体生物发生和肌肉萎缩相关基因的基因表达水平。这些结果表明，在日粮中添加 0.60% 牛磺酸的剂量可以减轻敌草快毒性引起的骨骼肌损伤。建议牛磺酸可能是一种潜在的营养干预策略，以提高生长性能。