A 5-year-old male, neutered mixed breed dog with a history of a mass with an associated draining tract on the ventral cervical region was diagnosed with an esophageal fistula. The dog exhibited serosanguinous discharge from the draining tract, with enlarged left superficial cervical and mandibular lymph nodes, and was reported to have difficulty with deglutition of solid foods. Computed tomography revealed a communication of the draining tract with the esophagus along with enlargement of the left lateral retropharyngeal, left medial retropharyngeal, and mandibular lymph nodes. This prompted surgical exploration and debridement of the site, with closure of the esophageal fistula. Histopathology of thyroid gland, skeletal muscle, and adipose tissue obtained during surgical exploration showed spherules consistent with Coccidioides spp. infection. Antibody titers performed post-operatively were consistent with an active Coccidioides spp. Infection. By fungal culture and subsequent PCR and DNA sequencing, C. posadasii was identified as the species infecting the dog. Over the course of 85 days of antifungal therapy, discharge from the draining tract, lymphadenomegaly, and cutaneous and subcutaneous nodules resolved. In conclusion, this is the first reported case of disseminated coccidioidomycosis to the cervical region of a dog with involvement of the thyroid gland, skeletal muscle, adipose tissue, connective tissue, and secondary esophageal fistula. Coccidioides spp. infections should be considered a differential diagnosis in unusual cases for dogs that live in or have traveled to endemic areas.

中文翻译：

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颈椎病并发食管瘘的狗中的球孢子。

一只5岁的雄性，绝育的混血狗被诊断患有食管瘘，该狗有肿块史，腹侧颈区伴有引流道。这只狗表现出从引流道排出的血清血性分泌物，左颈浅表和下颌淋巴结肿大，据报道很难分解固体食物。计算机体层摄影术显示，食道的引流道与左侧咽后外侧，左侧咽后内侧和下颌淋巴结肿大相通。这促使手术探查和清创该部位，并关闭了食管瘘。在手术探查过程中获得的甲状腺，骨骼肌和脂肪组织的组织病理学显示，小球与球孢子菌一致。感染。术后进行的抗体滴度与活性球虫属spp一致。感染。通过真菌培养以及随后的PCR和DNA测序，波氏梭菌被鉴定为感染狗的物种。在85天的抗真菌治疗过程中，引流道，淋巴腺肿大以及皮肤和皮下结节的分泌物得以解决。总之，这是首例报告的球虫球菌病传播到狗的子宫颈区域，并累及甲状腺，骨骼肌，脂肪组织，结缔组织和食管继发性瘘管。球虫科 对于生活在或已流行地区的狗，在特殊情况下应将感染视为鉴别诊断。通过真菌培养以及随后的PCR和DNA测序，波氏梭菌被鉴定为感染狗的物种。在85天的抗真菌治疗过程中，引流道，淋巴腺肿大以及皮肤和皮下结节的分泌物得以解决。总之，这是首例报告的球虫球菌病传播到狗的子宫颈区域，并累及甲状腺，骨骼肌，脂肪组织，结缔组织和食管继发性瘘管。球虫科 对于生活在或已流行地区的狗，在特殊情况下应将感染视为鉴别诊断。通过真菌培养以及随后的PCR和DNA测序，波氏梭菌被鉴定为感染狗的物种。在85天的抗真菌治疗过程中，引流道，淋巴腺肿大以及皮肤和皮下结节的分泌物得以解决。总之，这是首例报告的球虫球菌病传播到狗的子宫颈区域，并累及甲状腺，骨骼肌，脂肪组织，结缔组织和食管继发性瘘管。球虫科 对于生活在或已流行地区的狗，在特殊情况下应将感染视为鉴别诊断。从引流道，淋巴腺肿大，皮肤和皮下结节排出。总之，这是第一例报告的球虫球菌病传播到狗的颈部，并累及甲状腺，骨骼肌，脂肪组织，结缔组织和继发食管瘘的病例。球虫科 对于生活在或已流行地区的狗，在特殊情况下应将感染视为鉴别诊断。从引流道，淋巴腺肿大，皮肤和皮下结节排出。总之，这是第一例报告的球虫球菌病传播到狗的颈部，并累及甲状腺，骨骼肌，脂肪组织，结缔组织和继发食管瘘的病例。球虫科 对于生活在或已流行地区的狗，在特殊情况下应将感染视为鉴别诊断。