Recent studies on Myotonic dystrophy type 1 (DM1) have shown profound impairments in gait, leading to falls. We analyzed functional ambulation profile (FAP) score that reflects the temporal and spatial gait characteristics and investigated correlations with the lower limb muscle magnetic resonance imaging (MRI) and 6 min walk test (6MWT). Twenty patients with DM1 and 20 controls participated in this study. The 6MWT and gait analysis including FAP scores via GAITRite were performed in all patients and controls. DM1 patients displayed slower gait, shorter stride length, shorter stance length, and lower FAP score. Among lower extremity muscles, the gastrocnemius, soleus and tibialis anterior showed the most severe fat infiltration and these crural muscles significantly correlated with FAP and 6MWT. Among crural muscles, tibialis anterior was the most important muscle affecting gait speed, whereas the gastrocnemius contributed substantially to gait instability. FAP score correlated with the muscle imaging and 6MWT in DM1. Therefore, FAP score maybe used as an non-invasive marker that reflects deterioration of gait and a possible surrogate biomarker in DM1.

中文翻译：

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功能性行走曲线（FAP）得分是1型强直性营养不良患者步态分析的潜在标志。

对1型强直性肌营养不良症（DM1）的最新研究表明，步态严重受损，导致跌倒。我们分析了反映时间和空间步态特征的功能性步行特征（FAP）得分，并调查了与下肢肌肉磁共振成像（MRI）和6分钟步行测试（6MWT）的相关性。20名DM1患者和20名对照参加了这项研究。在所有患者和对照组中进行了6MWT和步态分析，包括通过GAITRite进行的FAP评分。DM1患者步态较慢，步幅较短，站立姿势较短，FAP评分较低。在下肢肌肉中，腓肠肌，比目鱼肌和胫骨前肌表现出最严重的脂肪浸润，这些关键肌与FAP和6MWT显着相关。在关键的肌肉中 胫前肌是影响步态速度最重要的肌肉，而腓肠肌则是导致步态不稳定的重要原因。FAP评分与DM1中的肌肉成像和6MWT相关。因此，FAP评分可用作反映步态恶化和DM1中可能的替代生物标志物的非侵入性标志物。