A versatile Cu-catalyzed direct ortho-C(sp²)–H amination of benzamides and picolinamides with alkylamines has been achieved. This method employs cheap and eco-friendly copper as a catalyst and oxygen as an oxidant, and also has the advantages of straightforward steps and excellent functional group compatibility. Further application of our approach was demonstrated by the synthesis of TCMDC-125116, SPHINX, and SRPIN340.

中文翻译：

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铜催化苯甲酰胺和吡啶甲酰胺与烷基胺的邻位C（sp2）-H氨化反应，使用氧气作为绿色氧化剂。

现已实现了一种多用途的Cu催化的苯甲酰胺和吡啶甲酰胺与烷基胺直接邻-C（sp ²）–H胺化反应。该方法使用廉价且环保的铜作为催化剂，并使用氧气作为氧化剂，并且还具有步骤简单，官能团相容性佳的优点。TCMDC-125116，SPHINX和SRPIN340的合成证明了我们方法的进一步应用。