Effects of altered blood flow induced by the muscle pump on thrombosis in a microfluidic venous valve model.,Lab on a Chip

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Effects of altered blood flow induced by the muscle pump on thrombosis in a microfluidic venous valve model.
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-06-09 , DOI: 10.1039/d0lc00287a
Xiangyu Hu ₁ , Yongjian Li , Jiang Li , Haosheng Chen

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Deep vein thrombosis (DVT) often occurs in the lower limb veins of bedridden patients and greatly reduces the quality of life. The altered blood flow in venous valves induced by the insufficient efficacy of the muscle pump is commonly considered as a main factor. However, it is still a great challenge to observe the altered blood flow in real time, and its role in the formation of thrombi is poorly understood. Here we make a microfluidic venous valve model with flexible leaflets in a deformable channel that can mimic the motion of valves and the compression of vessels by muscle contraction, and identify the stasis and intermittent reflux in the valve pocket generated by the muscle pump. A thrombus forms in the stasis flow, while the intermittent reflux removes the fibrin and inhibits the growth of the thrombus. A flexible microfluidic device that can mimic the motion of valves and the contraction of vessels would have wide applications in the research on cardiovascular diseases.

中文翻译：

在微流控静脉瓣膜模型中，由肌肉泵引起的血流改变对血栓形成的影响。

卧床不起的患者的下肢静脉常会发生深静脉血栓形成（DVT），大大降低了生活质量。通常认为由肌肉泵功效不足引起的静脉瓣膜血流改变是主要因素。然而，实时观察改变的血流仍然是一个巨大的挑战，人们对其血栓形成的作用了解甚少。在这里，我们建立了一个微流体的静脉瓣膜模型，该瓣膜模型在可变形的通道中具有柔性小叶，可以模拟瓣膜的运动和通过肌肉收缩对血管的压缩，并可以识别由肌肉泵产生的瓣膜袋中的淤滞和间歇性反流。血流中会形成血栓，而间歇性回流会去除血纤维蛋白并抑制血栓的生长。

更新日期：2020-07-14

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