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The rapid photoresponsive bacteria-killing of Cu-doped MoS2.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-06-09 , DOI: 10.1039/d0bm00872a
Chaofeng Wang 1 , Jun Li , Xiangmei Liu , Zhenduo Cui , Da-Fu Chen , Zhaoyang Li , Yanqin Liang , Shengli Zhu , Shuilin Wu
Affiliation  

Bacterial infection is a serious public health issue because this may cause bacterial pneumonia and bacteria-infected sepsis. The conventional antibiotic therapy can cause bacterial resistance and other adverse effects. Herein, we designed a novel photoresponsive hybrid, in which MoS2 nanosheets were doped with copper ions (MoS2@Cu2+). This system can effectively kill bacteria under 660 nm visible light irradiation due to enhanced photocatalytic and photothermal performances. The underlying mechanism is that when doping copper ions in MoS2, the photogenerated electrons can be rapidly transferred from the conduction band of MoS2 to copper ions, consequently reducing the electron–hole recombination, thereby enhancing the yield of radical oxygen species (ROS). Besides the intrinsic photothermal performance of MoS2, the Cu2+ ion can absorb photons and transfer the photoenergy into heat due to the d–d transition of electrons, resulting in enhanced photothermal properties of MoS2@Cu2+ compared with pristine MoS2. Therefore, owing to the synergistic action of hyperthermia, ROS and released Cu2+, this system exhibited highly effective antibacterial efficacy when exposed to 660 nm light for 20 min, i.e., 99.64% against Staphylococcus aureus. The cytotoxicity test showed that the synthesized MoS2@Cu2+ had good biocompatibility. This system will be a potential platform for environmental disinfection, healing of bacteria-infected wounds and other rapid bacteria-killing fields.

中文翻译:

Cu掺杂MoS2的快速光响应细菌杀灭。

细菌感染是一个严重的公共卫生问题,因为这可能导致细菌性肺炎和细菌感染的败血症。传统的抗生素治疗会引起细菌耐药性和其他不良反应。在此,我们设计了一种新型的光响应混合体,其中 MoS 2纳米片掺杂有铜离子(MoS 2 @Cu 2+)。由于增强的光催化和光热性能,该系统可以在 660 nm 可见光照射下有效杀灭细菌。其基本机制是当在MoS 2中掺杂铜离子时,光生电子可以从MoS 2的导带快速转移。铜离子,从而减少电子-空穴复合,从而提高自由基氧物种(ROS)的产率。除了 MoS 2的固有光热性能外,Cu 2+离子可以吸收光子并将光能通过电子的 d-d 跃迁转化为热能,与原始 MoS 2相比,MoS 2 @Cu 2+的光热性能增强. 因此,由于热疗、ROS和释放的Cu 2+的协同作用,该体系在660 nm光照射20 min时表现出高效的抗菌效果,即对金黄色葡萄球菌的抗菌率为99.64%。. 细胞毒性试验表明,合成的MoS 2 @Cu 2+具有良好的生物相容性。该系统将成为环境消毒、细菌感染伤口愈合和其他快速杀菌领域的潜在平台。
更新日期:2020-07-28
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