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Increased Dendritic Orientation Dispersion in the Left Occipital Gyrus is Associated with Atypical Visual Processing in Adults with Autism Spectrum Disorder.
Cerebral Cortex ( IF 3.7 ) Pub Date : 2020-06-09 , DOI: 10.1093/cercor/bhaa121
Kiwamu Matsuoka 1, 2 , Manabu Makinodan 2 , Soichiro Kitamura 1, 2 , Masato Takahashi 2 , Hiroaki Yoshikawa 2 , Fumihiko Yasuno 3 , Rio Ishida 2 , Naoko Kishimoto 2 , Yuka Yasuda 2, 4, 5 , Ryota Hashimoto 5, 6 , Toshiaki Taoka 7 , Toshiteru Miyasaka 8 , Kimihiko Kichikawa 8 , Toshifumi Kishimoto 2
Affiliation  

In autism spectrum disorder (ASD), the complexity-specific hypothesis explains that atypical visual processing is attributable to selective functional changes in visual pathways. We investigated dendritic microstructures and their associations with functional connectivity (FC). Participants included 28 individuals with ASD and 29 typically developed persons. We explored changes in neurite orientation dispersion and density imaging (NODDI) and brain areas whose FC was significantly correlated with NODDI parameters in the explored regions of interests. Individuals with ASD showed significantly higher orientation dispersion index (ODI) values in the left occipital gyrus (OG) corresponding to the secondary visual cortex (V2). FC values between the left OG and the left middle temporal gyrus (MTG) were significantly negatively correlated with mean ODI values. The mean ODI values in the left OG were significantly positively associated with low registration of the visual quadrants of the Adolescent/Adult Sensory Profile (AASP), resulting in a significant positive correlation with passive behavioral responses of the AASP visual quadrants; additionally, the FC values between the left OG and the left MTG were significantly negatively associated with reciprocal social interaction. Our results suggest that abnormal V2 dendritic arborization is associated with atypical visual processing by altered intermediation in the ventral visual pathway.

中文翻译:

左枕回的树突定向离散增加与自闭症谱系障碍成人的非典型视觉处理有关。

在自闭症谱系障碍 (ASD) 中,复杂性特定假设解释了非典型视觉处理可归因于视觉通路的选择性功能变化。我们研究了树枝状微结构及其与功能连接性 (FC) 的关联。参与者包括 28 名患有 ASD 的人和 29 名典型发展的人。我们探索了神经突方向分散和密度成像 (NODDI) 的变化以及其 FC 与探索的感兴趣区域中的 NODDI 参数显着相关的大脑区域。患有 ASD 的个体在对应于次级视觉皮层 (V2) 的左枕回 (OG) 中显示出显着更高的取向分散指数 (ODI) 值。左侧 OG 和左侧颞中回 (MTG) 之间的 FC 值与平均 ODI 值显着负相关。左侧 OG 的平均 ODI 值与青少年/成人感觉特征 (AASP) 视觉象限的低配准显着正相关,导致与 AASP 视觉象限的被动行为反应显着正相关;此外,左侧 OG 和左侧 MTG 之间的 FC 值与相互社会互动显着负相关。我们的研究结果表明,异常的 V2 树突状分支与腹侧视觉通路中改变的中介导致的非典型视觉处理有关。左侧 OG 的平均 ODI 值与青少年/成人感觉特征 (AASP) 视觉象限的低配准显着正相关,导致与 AASP 视觉象限的被动行为反应显着正相关;此外,左侧 OG 和左侧 MTG 之间的 FC 值与相互社会互动显着负相关。我们的研究结果表明,异常的 V2 树突状分支与腹侧视觉通路中改变的中介导致的非典型视觉处理有关。左侧 OG 的平均 ODI 值与青少年/成人感觉特征 (AASP) 视觉象限的低配准显着正相关,导致与 AASP 视觉象限的被动行为反应显着正相关;此外,左侧 OG 和左侧 MTG 之间的 FC 值与相互社会互动显着负相关。我们的研究结果表明,异常的 V2 树突状分支与腹侧视觉通路中改变的中介导致的非典型视觉处理有关。左侧 OG 和左侧 MTG 之间的 FC 值与相互社会互动显着负相关。我们的研究结果表明,异常的 V2 树突状分支与腹侧视觉通路中改变的中介导致的非典型视觉处理有关。左侧 OG 和左侧 MTG 之间的 FC 值与相互社会互动显着负相关。我们的研究结果表明,异常的 V2 树突状分支与腹侧视觉通路中改变的中介导致的非典型视觉处理有关。
更新日期:2020-06-09
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