Glycosyltransferase-Induced Morphology Transition of Glycopeptide Self-Assemblies with Proteoglycan Residues,ACS Macro Letters

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Glycosyltransferase-Induced Morphology Transition of Glycopeptide Self-Assemblies with Proteoglycan Residues
ACS Macro Letters ( IF 5.1 ) Pub Date : 2020-06-09 , DOI: 10.1021/acsmacrolett.0c00306
Jing Yang , Qiqige Du , Long Li , Tingting Wang _{1,

2} , Yingle Feng , Mu-Ping Nieh , Juzheng Sheng _{1,

2} , Guosong Chen

Affiliation

We previously proposed the deprotection-induced block copolymer self-assembly (DISA), that is, the deprotection of hydroxyl groups of saccharides resulted in self-assembly of glycopolymers (Qi et al. J. Am. Chem. Soc.2018, 140 (28), 8851–8857 and Su et al. ACS Macro Lett.2014, 3 (6), 534–539). In this study, we further combined glycochemistry and self-assembly strategy by introducing glycosyltransferase as the trigger, which constructs another glycosidic bonds and another carbohydrate building blocks in situ. Herein, we propose to utilize glycosyltransferase to induce the morphology transition of glycopeptide assemblies in the process of glycosidic bonds construction, which has never been reported in literature. This strategy provides us an alternative tool to construct proteoglycan-mimicking polymeric materials and deepens our understanding on the natural process of proteoglycan construction better in the future.

中文翻译：

糖基转移酶诱导的糖肽自组装与蛋白多糖残基的形态转变

我们之前提出了脱保护诱导嵌段共聚物自组装（DISA），即糖类羟基的脱保护导致糖聚合物的自组装（Qi et al. J. Am. Chem. Soc. 2018 , 140 ( 28), 8851–8857 和 Su et al. ACS Macro Lett. 2014 , 3(6), 534–539)。在这项研究中，我们通过引入糖基转移酶作为触发器，进一步结合糖化学和自组装策略，在原位构建另一个糖苷键和另一个碳水化合物构件。在此，我们建议利用糖基转移酶在糖苷键构建过程中诱导糖肽组装体的形态转变，这在文献中从未报道过。该策略为我们提供了一种构建蛋白多糖模拟聚合物材料的替代工具，并在未来更好地加深了我们对蛋白多糖构建自然过程的理解。

更新日期：2020-07-21

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