Introduction

Cyclodextrins (CDs) have been used extensively in inclusion complexes to improve the biological efficacy of complexed substances as well as to provide increased solubility and stability. We reviewed in vivo experimental studies of drug molecules complexed in cyclodextrins to evaluate whether these complexes improved bioavailability and enhanced the treatment of cancer, the second leading cause of death globally.

Area covered

The search terms cyclodextrins, anti-cancer, and cancer treatment were used to identify peer-reviewed publications limited to the English language in the PubMed, EMBASE, Scopus, and Web of Science electronic databases published from inception until July 2019. A total of 2760 studies were identified, of which 12 met the inclusion criteria. The review showed that cyclodextrin/anticancer drug complexes enhance solubility, reduce toxicity, and improve therapeutic efficacy in in vivo tumor models in the pharmacokinetic studies detailed and described below.

Expert opinion

The use of cyclodextrins combined with anticancer agents can provide better encapsulation and effective delivery of drugs to optimize their efficacy. Cyclodextrin inclusion complexes might also be a promising tool to lower the therapeutic dosage levels and thereby increase the safety and curative potential of the chemotherapeutic molecules.

中文翻译：

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环糊精包合物的使用改善抗癌药物的特性：系统评价。

介绍

环糊精（CD）已广泛用于包合物中，以改善复合物的生物功效，并提供增加的溶解度和稳定性。我们回顾了在环糊精中复合的药物分子的体内实验研究，以评估这些复合物是否改善了生物利用度并增强了癌症的治疗，癌症是全球第二大死亡原因。

覆盖面积

搜索词环糊精，抗癌和癌症治疗被用于识别从开始到2019年7月出版的PubMed，EMBASE，Scopus和Web of Science电子数据库中仅限于英语的经过同行评审的出版物。总共2760确定了研究，其中12个符合纳入标准。该综述表明，在下文详述和描述的药代动力学研究中，环糊精/抗癌药物复合物可提高体内肿瘤模型的溶解度，降低毒性并提高治疗功效。

专家意见

环糊精与抗癌药联合使用可提供更好的封装效果和有效的药物递送，以优化其功效。环糊精包合复合物也可能是降低治疗剂量水平从而增加化学治疗分子的安全性和治疗潜力的有前途的工具。