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Cell-laden alginate hydrogels for the treatment of diabetes.
Expert Opinion on Drug Delivery ( IF 5.0 ) Pub Date : 2020-08-12 , DOI: 10.1080/17425247.2020.1778667
Lukin Izeia 1, 2 , Tatiane Eufrasio-da-Silva 3 , Alireza Dolatshahi-Pirouz 3, 4 , Serge Ostrovidov 5 , Giovanna Paolone 6 , Nicholas A Peppas 7 , Paul De Vos 8 , Dwaine Emerich 9 , Gorka Orive 1, 2, 10, 11
Affiliation  

ABSTRACT

Introduction

Diabetes mellitus is an ever-increasing medical condition that currently suffers 1 of 11 adults who may have lifelong commitment with insulin injections. Cell-laden hydrogels releasing insulin may provide the ultimate means of correcting diabetes. Here, we provide insights of this cell-based approach including latest preclinical and clinical progress both from academia and industry.

Area covered

The present article focuses on reviewing latest advances in cell-laden hydrogels both from the technological and biological perspective. The most relevant clinical results including clinical trials are also discussed.

Expert opinion

Current progress in technological issues (stem cells, devices, biomaterials) have contributed cell encapsulation science to have a very relevant progress in the field of diabetes treatment.



中文翻译:

载有细胞的藻酸盐水凝胶可用于治疗糖尿病。

摘要

介绍

糖尿病是一种不断增加的疾病,目前有11位成年人中有1位可能会终身注射胰岛素。释放胰岛素的充满细胞的水凝胶可能提供纠正糖尿病的最终手段。在这里,我们提供了这种基于细胞的方法的见解,包括学术界和工业界的最新临床前和临床进展。

覆盖面积

本文重点从技术和生物学的角度回顾载有细胞的水凝胶的最新进展。还讨论了最相关的临床结果,包括临床试验。

专家意见

技术问题(干细胞,设备,生物材料)方面的最新进展促进了细胞封装科学的发展,从而在糖尿病治疗领域取得了非常重要的进展。

更新日期:2020-08-14
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