Cell-laden alginate hydrogels for the treatment of diabetes.,Expert Opinion on Drug Delivery

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Cell-laden alginate hydrogels for the treatment of diabetes.
Expert Opinion on Drug Delivery ( IF 5.0 ) Pub Date : 2020-08-12 , DOI: 10.1080/17425247.2020.1778667
Lukin Izeia _{1,

2} , Tatiane Eufrasio-da-Silva ₃ , Alireza Dolatshahi-Pirouz _{3,

4} , Serge Ostrovidov ₅ , Giovanna Paolone ₆ , Nicholas A Peppas ₇ , Paul De Vos ₈ , Dwaine Emerich ₉ , Gorka Orive _{1,

2,

10,

11}

Affiliation

NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU , Vitoria-Gasteiz, Spain.
Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , Vitoria-Gasteiz, Spain.
Department of Dentistry - Regenerative Biomaterials, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences , Nijmegen, The Netherlands.
Department of Health Technology, Institute of Biotherapeutic Engineering and Drug Targeting, Center for Intestinal Absorption and Transport of Biopharmaceuticals Technical University of Denmark , Lyngby, Denmark.
Center for Minimally Invasive Therapeutics (C-MIT) Department of Radiological Sciences, University of California , Los Angeles, CA, USA.
Department of Diagnostic and Public Health, Section of Pharmacology, University of Verona , Verona, Italy.
Departments of Pharmaceutics, Chemical and Biomedical Engineering, The University of Texas at Austin , Austin, TX, USA.
Pathology and Medical Biology Section, Immunoendocrinology, University of Groningen , Groningen, The Netherlands.
Gloriana Therapeutics, Inc. (Formerly NsGene Inc.) , Providence, RI, USA.
University Institute for Regenerative Medicine and Oral Implantology - UIRMI (Upv/ehu-fundación Eduardo Anitua) , Vitoria, Spain.
The Academia, Singapore Eye Research Institute , Discovery Tower, Singapore.

ABSTRACT

Introduction

Diabetes mellitus is an ever-increasing medical condition that currently suffers 1 of 11 adults who may have lifelong commitment with insulin injections. Cell-laden hydrogels releasing insulin may provide the ultimate means of correcting diabetes. Here, we provide insights of this cell-based approach including latest preclinical and clinical progress both from academia and industry.

Area covered

The present article focuses on reviewing latest advances in cell-laden hydrogels both from the technological and biological perspective. The most relevant clinical results including clinical trials are also discussed.

Expert opinion

Current progress in technological issues (stem cells, devices, biomaterials) have contributed cell encapsulation science to have a very relevant progress in the field of diabetes treatment.

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