ABSTRACT

The potential of fused filament fabrication (FFF) for the administration of active pharmaceutical compounds is a recent approach to develop complex and custom-made drug delivery systems (DDSs). However, the FFF technology is characterized by certain limitations, which are associated with the nature of the process, i.e., the required mechanical properties of the feedstock, as well as the thermal stability of the incorporated polymers, excipients and active compounds. Thus, hybrid DDSs have been recently introduced, to overcome these boundaries. The concept of these systems is defined by the effective coupling of FFF with conventional manufacturing technologies, as a novel pathway to expand the available pool of raw materials and pharmaceutical applications of FFF.

摘要

熔融长丝制造（FFF）用于活性药物化合物给药的潜力是开发复杂和定制的药物递送系统（DDS）的最新方法。然而，FFF技术的特征在于某些限制，这些限制与方法的性质有关，即原料的所需机械性能以及所掺入的聚合物，赋形剂和活性化合物的热稳定性。因此，近来引入了混合DDS以克服这些边界。这些系统的概念是通过FFF与传统制造技术的有效结合来定义的，这是一种扩展FFF原材料和制药应用的新途径。