The interleukin-17 (IL-17) family is a relatively new family of cytokines consisting of 6 related factors (IL-17A–IL-17F), while the receptor family consists of 5 members: IL-17RA–IL-17RE. IL-17A is the prototype member of this family, which is also the signature cytokine of T helper 17 (Th17) cells. Th17 cells are involved in the development of autoimmune disease, inflammation, and tumors. Although IL-17D is similar to IL-17A in its ability to induce inflammatory cytokine production, there are fewer studies on IL-17D. Recently, the role of IL-17D in tumors and infections has attracted our attention. Some knowledge of function of IL-17D has been gained by studies using nonmammalian species. In this review, we introduce the structural characteristics, expression patterns, and biological characteristics of IL-17D along with its potential function in the pathogenesis of disease.
Int Arch Allergy Immunol

中文翻译：

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IL-17D：IL-17家族研究较少的细胞因子。

白介素17（IL-17）家族是一个相对较新的细胞因子家族，由6个相关因子（IL-17A–IL-17F）组成，而受体家族则由5个成员组成：IL-17RA–IL-17RE。IL-17A是该家族的原型成员，也是T辅助17（Th17）细胞的标志性细胞因子。Th17细胞参与自身免疫性疾病，炎症和肿瘤的发展。尽管IL-17D在诱导炎症性细胞因子产生方面与IL-17A相似，但有关IL-17D的研究较少。最近，IL-17D在肿瘤和感染中的作用吸引了我们的注意力。通过使用非哺乳动物种类的研究已经获得了有关IL-17D功能的一些知识。在这篇评论中，我们介绍了结构特征，表达模式，
Int Arch过敏免疫