RNA-directed DNA methylation has an important developmental function in Arabidopsis that is masked by the chromatin remodeler PICKLE.,Journal of Integrative Plant Biology

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RNA-directed DNA methylation has an important developmental function in Arabidopsis that is masked by the chromatin remodeler PICKLE.
Journal of Integrative Plant Biology ( IF 9.3 ) Pub Date : 2020-06-09 , DOI: 10.1111/jipb.12979
Rong Yang ₁ , Li He ₁ , Huan Huang ₁ , Jian-Kang Zhu _{1,

2} , Rosa Lozano-Duran ₁ , Heng Zhang _{1,

3}

Affiliation

In Arabidopsis, RNA‐directed DNA methylation (RdDM) is required for the maintenance of CHH methylation, and for de novo methylation in all (CG, CHG, and CHH) contexts, but no obvious effect of RdDM deficiency on plant development has been found to date. We show that the combination of mutations in the chromatin remodeler PKL and RdDM components results in developmental alterations, which appear in a SUPPRESSOR OF DRM1 DRM2 CMT3 (SDC)‐dependent manner.

中文翻译：

RNA定向的DNA甲基化在拟南芥中具有重要的发育功能，被染色质重塑剂PICKLE掩盖。

在拟南芥中，需要RNA指导的DNA甲基化（RdDM）来维持CHH甲基化，并在所有情况下（CG，CHG和CHH）进行从头甲基化，但未发现RdDM缺乏对植物发育的明显影响至今。我们显示，染色质重塑剂PKL和RdDM组件中突变的组合会导致发育变化，这种变化以DRM1 DRM2 CMT3（SDC）依赖性抑制子的形式出现。

更新日期：2020-06-09

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