Staphylococcus aureus is known as a common pathogen that colonizes 30% of healthy humans. Additionally, this bacterium can cause a number of serious infections, that is, endocarditis, bacteremia, pneumonia, wound, skin infections, and tissue abscesses. A variety of cellular and molecular pathways and targets are involved in response against S. aureus. Among them, microRNAs (miRNAs) have crucial roles in response against S. aureus. In this regard, it has been shown that these molecules exert their regulatory roles via modulating a wide range of events, such as inflammatory reactions, host innate, and adaptive immunity. Current works have provided insight into the crucial involvement of miRNAs in immune defense toward Staphylococcal infections. Herein, we highlighted the current findings on the deregulation of different miRNAs in S. aureus-infected cells. Moreover, we summarized the mechanisms and targets of miRNAs in S. aureus infections.

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microRNA 在金黄色葡萄球菌感染中的作用：潜在的生物标志物和机制

金黄色葡萄球菌被认为是一种常见的病原体，30% 的健康人都可以定植。此外，这种细菌会引起许多严重的感染，即心内膜炎、菌血症、肺炎、伤口、皮肤感染和组织脓肿。多种细胞和分子途径和靶点参与对金黄色葡萄球菌的反应。其中，microRNAs (miRNAs) 在对抗金黄色葡萄球菌的反应中起着至关重要的作用。在这方面，已经表明这些分子通过调节广泛的事件发挥其调节作用，例如炎症反应、宿主先天性免疫和适应性免疫。目前的工作已经提供了对 miRNA 在针对葡萄球菌感染的免疫防御中的关键参与的深入了解。在此，我们重点介绍了目前关于金黄色葡萄球菌中不同 miRNA 失调的发现。金黄色葡萄球菌感染的细胞。此外，我们总结了 miRNA 在金黄色葡萄球菌感染中的机制和靶点。