This review discusses the definition and major categories of cutaneous T‐cell lymphoma, Sézary syndrome and mycosis fungoides, and the role of immunophenotyping in their diagnosis. The following key points are raised: (a) Sézary syndrome and mycosis fungoides cells most often have a characteristic CD3+ CD4+ CD7− and/or CD26− immunophenotype. (b) This immunophenotype is not specific, but can assist in the distinction from non‐neoplastic T cells and other subtypes of mature T‐cell neoplasm. (c) However, small subsets of normal and reactive T‐cells can have an overlapping immunophenotype, and can be distinguished by evaluating for additional changes in antigen expression.

中文翻译：

---

Sézary 综合征和蕈样肉芽肿：概述，包括免疫表型的作用

这篇综述讨论了皮肤 T 细胞淋巴瘤、Sézary 综合征和蕈样肉芽肿的定义和主要类别，以及免疫表型在诊断中的作用。提出以下要点： (a) Sézary 综合征和蕈样肉芽肿细胞最常具有特征性 CD3+ CD4+ CD7- 和/或 CD26- 免疫表型。(b) 这种免疫表型没有特异性，但可以帮助区分非肿瘤性 T 细胞和其他成熟 T 细胞肿瘤亚型。(c) 然而，一小部分正常和反应性 T 细胞可能具有重叠的免疫表型，并且可以通过评估抗原表达的其他变化来区分。