In asthma, sensitization to fungal, perennial or seasonal allergens increases the risk of uncontrolled symptoms, exacerbations, and poor disease outcomes.In severe asthma, typically 20%-29% of patients show sensitization to ≥1 fungal allergen, with Aspergillus being one of the most common.These patients have worse lung function, increased risk of oral corticosteroid use, hospitalization, and a greater degree of airflow obstruction than patients non-sensitized to fungal allergens.

中文翻译：

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重度嗜酸性粒细胞性哮喘患者的真菌致敏及其与美泊利单抗反应的关系

在哮喘中，对真菌、常年性或季节性过敏原过敏会增加症状不受控制、恶化和疾病结果不佳的风险。在严重哮喘中，通常有 20%-29% 的患者对≥1 种真菌过敏原过敏，曲霉菌是其中之一最常见。与对真菌过敏原不敏感的患者相比，这些患者的肺功能更差，使用口服皮质类固醇的风险增加，住院治疗和气流阻塞程度更高。