The goal was to compare static magnetic field (SMF, generated by Nd₂–Fe₁₄–B magnets) vasodilator capacity with verapamil (VER, a potent, clinically verified Ca²⁺ channel‐blocking agent), aimed to assess SMF implementation in conditions with vascular ischemia. Skin microcirculatory blood flow measured by microphotoelectric plethysmogram was recorded in conscious rabbits after 40 min of 0.25 T SMF regional exposure to ear microvascular net (SMF‐Vas, n = 20), or 0.35 T to carotid baroreceptors (SMF‐Car, n = 14), and compared with that after 30 min VER intravenous infusion (20 µg/kg/min, n = 20). The principal finding is that SMF‐Vas, SMF‐Car, and VER significantly increased microcirculatory blood flow by 17.9 ± 9.58%, 22.6 ± 11.11%, and 30.5 ± 14.06% (mean ± SEM) respectively, and there was no significant difference between all three treatments (P = 0.986). Microvascular dilation was accompanied by significant decrease of blood pressure in VER and SMF‐Car cases. The decrease of arterial baroreflex sensitivity in VER contrasted with its increase in SMF‐Car, coupled with improved vessel sensitivity to nitric oxide (NO) dilatory effect. This suggests that SMF can have a strong vasodilator property tailored to address diabetic, mainly NO‐deficient, neural, and myogenic microvascular dysfunction, especially employing both SMFs’ vasodilation synergy. Bioelectromagnetics. 2020;41:447–457. © 2020 Bioelectromagnetics Society.

中文翻译：

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静磁场与系统钙通道对微循环的阻断作用：可能的机制和临床实施。

目的是比较静磁场（由Nd ₂ -Fe ₁₄ -B磁体产生的SMF ）和维拉帕米（VER，一种经过临床验证的有效Ca ²⁺通道阻滞剂）的血管扩张能力，旨在评估在一定条件下的SMF实施情况与血管缺血。在0.25 T SMF区域暴露于耳微血管网（SMF‐Vas，n  = 20）或颈动脉压力感受器（SMF‐Car，n  = 14 ）0.35 T后40分钟，在有意识的兔子中记录了通过微光电体积描记法测量的皮肤微循环血流量），并与VER静脉输注30分钟（20 µg / kg / min，n = 20）。主要发现是SMF-Vas，SMF-Car和VER分别显着增加了微循环血流量17.9±9.58％，22.6±11.11％和30.5±14.06％（平均值±SEM），并且两者之间无显着差异三种治疗方法（P = 0.986）。在VER和SMF-Car病例中，微血管扩张伴有血压显着下降。VER中动脉压力反射敏感性的降低与其SMF-Car的升高相反，同时血管对一氧化氮（NO）扩张作用的敏感性也得到了提高。这表明SMF可以具有强大的血管舒张特性，专门针对糖尿病，主要是NO缺乏，神经和肌源性微血管功能障碍而设计，尤其是同时利用SMF的血管舒张协同作用。生物电磁学。2020; 41：447-457。©2020生物电磁学会。