Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins.,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-06-08 , DOI: 10.1002/anie.202003825
Florian A Mann ₁ , Niklas Herrmann ₁ , Felipe Opazo ₂ , Sebastian Kruss ₁

Affiliation

Single‐walled carbon nanotubes (SWCNTs) are a 1D nanomaterial that shows fluorescence in the near‐infrared (NIR, >800 nm). In the past, covalent chemistry was less explored to functionalize SWCNTs as it impairs NIR emission. However, certain sp³ defects (quantum defects) in the carbon lattice have emerged that preserve NIR fluorescence and even introduce a new, red‐shifted emission peak. Here, we report on quantum defects, introduced using light‐driven diazonium chemistry, that serve as anchor points for peptides and proteins. We show that maleimide anchors allow conjugation of cysteine‐containing proteins such as a GFP‐binding nanobody. In addition, an Fmoc‐protected phenylalanine defect serves as a starting point for conjugation of visible fluorophores to create multicolor SWCNTs and in situ peptide synthesis directly on the nanotube. Therefore, these quantum defects are a versatile platform to tailor both the nanotube's photophysical properties as well as their surface chemistry.

中文翻译：

量子缺陷作为碳纳米管与肽和蛋白质共价功能化的工具箱。

单壁碳纳米管 (SWCNT) 是一种一维纳米材料，在近红外（NIR，>800 nm）范围内显示荧光。过去，共价化学很少被用于功能化单壁碳纳米管，因为它会损害近红外发射。然而，碳晶格中出现了某些 sp ³缺陷（量子缺陷），它们保留了近红外荧光，甚至引入了新的红移发射峰。在这里，我们报告了使用光驱动重氮化学引入的量子缺陷，这些缺陷充当肽和蛋白质的锚点。我们证明马来酰亚胺锚允许缀合含半胱氨酸的蛋白质，例如 GFP 结合纳米抗体。此外，Fmoc 保护的苯丙氨酸缺陷可作为可见荧光团缀合的起点，以创建多色 SWCNT 并直接在纳米管上进行原位肽合成。因此，这些量子缺陷是一个通用平台，可以调整纳米管的光物理性质及其表面化学性质。

更新日期：2020-06-08

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11