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Single-Cell Genomics and Epigenomics: Technologies and Applications in Plants.
Trends in Plant Science ( IF 17.3 ) Pub Date : 2020-06-09 , DOI: 10.1016/j.tplants.2020.04.016
Cheng Luo 1 , Alisdair R Fernie 2 , Jianbing Yan 1
Affiliation  

The development of genomics and epigenomics has allowed rapid advances in our understanding of plant biology. However, conventional bulk analysis dilutes cell-specific information by providing only average information, thereby limiting the resolution of genomic and functional genomic studies. Recent advances in single-cell sequencing technology concerning genomics and epigenomics open new avenues to dissect cell heterogeneity in multiple biological processes. Recent applications of these approaches to plants have provided exciting insights into diverse biological questions. We highlight the methodologies underlying the current techniques of single-cell genomics and epigenomics before covering their recent applications, potential significance, and future perspectives in plant biology.



中文翻译:

单细胞基因组学和表观基因组学:植物中的技术和应用。

基因组学和表观基因组学的发展使我们对植物生物学的理解有了快速的发展。然而,常规的批量分析通过仅提供平均信息来稀释细胞特异性信息,从而限制了基因组和功能基因组研究的分辨率。有关基因组学和表观基因组学的单细胞测序技术的最新进展为剖析多种生物过程中的细胞异质性开辟了新途径。这些方法在植物中的最新应用为各种生物学问题提供了令人兴奋的见解。在介绍单细胞基因组学和表观基因组学当前技术的基础之前,我们将重点介绍它们的最新应用,潜在意义以及植物生物学的未来前景。

更新日期:2020-06-09
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