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Blue light-promoted N–H insertion of amides, isatins, sulfonamides and imides into aryldiazoacetates: Synthesis of unnatural α-aryl amino acid derivatives
Tetrahedron ( IF 2.1 ) Pub Date : 2020-06-09 , DOI: 10.1016/j.tet.2020.131316
Celso Y. Okada , Caio Y. dos Santos , Igor D. Jurberg

A photochemical protocol using blue light allows the N–H insertion of amides, isatins, sulfonamides and imides into aryldiazoacetates to afford the corresponding α-amino esters. This method is experimentally simple, inexpensive and tolerates numerous functional groups, thus allowing the straightforward preparation of a variety of α-aryl amino acid derivatives in good yields.



中文翻译:

蓝光促进酰胺,靛红,磺酰胺和酰亚胺在芳重氮基乙酸酯中的NH插入:非天然α-芳基氨基酸衍生物的合成

使用蓝光的光化学方法可以使酰胺,靛红,磺酰胺和酰亚胺的N–H插入芳基重氮乙酸酯中,得到相应的α-氨基酯。该方法在实验上是简单的,廉价的并且耐受许多官能团,因此允许以良好的产率直接制备多种α-芳基氨基酸衍生物。

更新日期:2020-06-09
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