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Systematic review with meta-analysis of partial enteral nutrition for maintenance of remission in Crohn’s disease
Nutrition Research ( IF 3.4 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.nutres.2020.06.006
Hongsheng Yang 1 , Rui Feng 2 , Tong Li 2 , Shu Xu 2 , Xiuxue Hao 2 , Yun Qiu 2 , Minhu Chen 2
Affiliation  

Although enteral nutrition (EN) is effective for induction therapy in Crohn's disease (CD), it remains unclear whether partial enteral nutrition (PEN), i.e., EN, along with a daily diet, is effective for maintenance therapy in CD. It was hypothesized that PEN would be effective as a maintenance therapy in CD. This meta-analysis aimed to evaluate the efficacy and safety of PEN for maintenance therapy in CD. PubMed, EMBASE, Web of Science, and Cochrane Library were searched up to January 2019 for eligible prospective controlled trials, and then a meta-analysis was conducted. The primary outcome was clinical relapse, as defined in the primary studies. Eight studies with 429 patients were included in the meta-analysis. The rate of clinical relapse at 0.5 to 2 years was significantly lower in patients receiving PEN (420-1800 kcal/d) than in those not receiving nutrition therapy (RR: 0.67, 95% CI: 0.54-0.82, P < .01; number needed to treat = 5, P < .01). Patients receiving PEN exhibited a higher frequency of clinical remission maintenance at 0.5 to 1 year (67%) than did those not receiving nutrition therapy (48%; RR: 1.32, 95% CI: 1.07-1.64, P = .01). The total adverse event rate was comparable in the two groups (RR: 3.60, 95% CI: 0.70-18.66, P = .13). PEN may be more effective than the absence of EN therapy for the maintenance of remission in CD with a good safety profile.

中文翻译:

部分肠内营养维持克罗恩病缓解的荟萃分析的系统评价

尽管肠内营养 (EN) 对克罗恩病 (CD) 的诱导治疗有效,但部分肠内营养 (PEN),即 EN,连同日常饮食,是否对 CD 的维持治疗有效仍不清楚。假设 PEN 作为 CD 的维持治疗是有效的。本荟萃分析旨在评估 PEN 在 CD 维持治疗中的有效性和安全性。检索了 PubMed、EMBASE、Web of Science 和 Cochrane Library 直至 2019 年 1 月的符合条件的前瞻性对照试验,然后进行了荟萃分析。主要结果是临床复发,如主要研究中所定义。荟萃分析包括八项涉及 429 名患者的研究。临床复发率为 0。接受 PEN (420-1800 kcal/d) 的患者的 5 至 2 年显着低于未接受营养治疗的患者(RR:0.67,95% CI:0.54-0.82,P < .01;需要治疗的人数 = 5 , P < .01)。与未接受营养治疗的患者相比,接受 PEN 的患者在 0.5 至 1 年(67%)表现出更高的临床缓解维持频率(48%;RR:1.32,95% CI:1.07-1.64,P = .01)。两组的总不良事件发生率相当(RR:3.60,95% CI:0.70-18.66,P = .13)。PEN 可能比不使用 EN 治疗更有效地维持 CD 的缓解并具有良好的安全性。5 至 1 年 (67%) 比未接受营养治疗的患者 (48%;RR:1.32,95% CI:1.07-1.64,P = .01)。两组的总不良事件发生率相当(RR:3.60,95% CI:0.70-18.66,P = .13)。PEN 可能比不使用 EN 治疗更有效地维持 CD 的缓解并具有良好的安全性。5 至 1 年 (67%) 比未接受营养治疗的患者 (48%;RR:1.32,95% CI:1.07-1.64,P = .01)。两组的总不良事件发生率相当(RR:3.60,95% CI:0.70-18.66,P = .13)。PEN 可能比不使用 EN 治疗更有效地维持 CD 的缓解并具有良好的安全性。
更新日期:2020-09-01
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