Abstract One of the most common ways of getting rid of sewage sludge is land spreading on agricultural fields as a source of nutrients and organic matter. However, sewage sludge may be contaminated with pharmaceuticals and can represent a cause of environmental contamination. The objectives of this study was (i) to determine the occurrence and the fate of pharmaceuticals such as antibiotics belonging to different classes: antibiotics (sulfadiazine, sulfamethoxazole, sulfamethoxypyridazine, ciprofloxacin, norfloxacin, tylosin, trimethoprim), anti-inflammatories (diclofenac) and anticonvulsants (carbamazepine) in the soil after spreading stabilized sludge (composted, limed and digested) and solid digestat, (ii) to evaluate agronomic benefits and (iii) to determine the potential ecotoxicological consequences of pharmaceutical compounds on the environment using a risk quotient approach. For this purpose, four different types of sludge samples, coming from the same treatment plant but submitted to different stabilization processes, were incorporated into three soils with different physicochemical characteristics and pedogenetic factors. The obtained results highlighted that the sludge treatments have a great influence on sludge contamination. Once applied onto the soil, the agronomic benefits will depend on the soil’s properties as well as the sludge’s characteristics. The risks concerning the ecotoxicity of pharmaceuticals, found in the sludge, are low but not insignificant.

中文翻译：

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有机废物改良土壤中药物化合物的发生、归宿和环境风险评估

摘要 去除污水污泥最常见的方法之一是在农田上撒播土地，作为营养物质和有机物的来源。然而，污水污泥可能被药物污染，并且可能是环境污染的一个原因。本研究的目的是 (i) 确定药物如属于不同类别的抗生素的发生和归宿：抗生素（磺胺嘧啶、磺胺甲恶唑、磺胺甲氧哒嗪、环丙沙星、诺氟沙星、泰乐菌素、甲氧苄啶）、抗炎药（双氯芬酸）和将稳定的污泥（堆肥、石灰和消化）和固体消化物撒播后，土壤中的抗惊厥药（卡马西平），(ii) 评估农艺效益和 (iii) 使用风险商数方法确定药物化合物对环境的潜在生态毒理学后果。为此，来自同一处理厂但经过不同稳定过程的四种不同类型的污泥样品被合并到具有不同理化特性和成土因素的三种土壤中。所得结果强调污泥处理对污泥污染有很大影响。一旦施用于土壤，农艺效益将取决于土壤的特性以及污泥的特性。在污泥中发现的药物生态毒性风险很低，但并非微不足道。来自同一处理厂但经过不同稳定过程的四种不同类型的污泥样品被合并到具有不同理化特性和成土因素的三种土壤中。所得结果强调污泥处理对污泥污染有很大影响。一旦施用于土壤，农艺效益将取决于土壤的特性以及污泥的特性。在污泥中发现的药物生态毒性风险很低，但并非微不足道。来自同一处理厂但经过不同稳定过程的四种不同类型的污泥样品被纳入具有不同理化特性和成土因素的三种土壤中。所得结果强调污泥处理对污泥污染有很大影响。一旦施用于土壤，农艺效益将取决于土壤的特性以及污泥的特性。在污泥中发现的药物生态毒性风险很低，但并非微不足道。所得结果强调污泥处理对污泥污染有很大影响。一旦施用于土壤，农艺效益将取决于土壤的特性以及污泥的特性。在污泥中发现的药物生态毒性风险很低，但并非微不足道。所得结果强调污泥处理对污泥污染有很大影响。一旦施用于土壤，农艺效益将取决于土壤的特性以及污泥的特性。在污泥中发现的药物生态毒性风险很低，但并非微不足道。