The recent approval of Immunologic checkpoint inhibitors as an effective therapeutic strategy against cancer came at the cost of toxicities mediated by an excessive activation of immune system against health tissues, including among others musculoskeletal and sicca complaints.The latter occur in the context of an entity reminiscent of Sjogren's syndrome, with distinct characteristics such as abrupt onset, male predominance, lower prevalence of autoantibodies and response to steroids.

中文翻译：

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免疫检查点抑制后的Sicca综合征。

免疫学检查点抑制剂最近被批准作为一种有效的癌症治疗策略，是以毒性反应为代价的，这种毒性是由针对健康组织的免疫系统过度激活所介导的，包括肌肉骨骼和中枢神经系统的不适，后者发生在让人联想到实体的情况下干燥综合征的特征，如突然发作，男性占优势，自身抗体患病率较低和对类固醇的反应。