The double-sensitive graft copolymers of sodium salt of carboxymethyl cellulose (Na-CMC) and N,N-dimethylaminoethyl methacrylate (DMAEMA) with different content are successfully synthesized by radical polymerization applying a redox initiator. Aqueous solution of the synthesized copolymers has a lower critical solution temperature (LCST) in the range of 37–44 °C, and the sizes of copolymer particles being multichain spherical negative-charged aggregates are in a 118–133 nm range. Na-CMC-g-PDMAEMA copolymer particles are stable in a 0.15 N NaCl aqueous solution and in the physiological pH range, which allows to apply them as vectors for targeted drug delivery. Conjugation between Paclitaxel (Ptx) and Na-CMC-g-PDMAEMA copolymer is due to hydrophobic and electrostatic interaction between functional groups of each component; copolymers are characterized by relatively high values of loading and encapsulation efficiencies of Ptx. In vitro release kinetics was also researched in acidic and neutral media at 38 °C. The release process of Ptx from a copolymer conjugate is described by Korsmeyer–Peppas kinetic model and limited by molecular diffusion.

中文翻译：

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羧甲基纤维素与甲基丙烯酸N,N-二甲氨基乙酯接枝共聚物的合成及其作为紫杉醇载体的研究

采用氧化还原引发剂自由基聚合，成功合成了不同含量的羧甲基纤维素钠盐(Na-CMC)与甲基丙烯酸N,N-二甲氨基乙酯(DMAEMA)双敏接枝共聚物。合成共聚物的水溶液具有较低的临界溶解温度 (LCST)，范围为 37–44 °C，多链球形带负电荷聚集体的共聚物颗粒尺寸在 118–133 nm 范围内。Na-CMC-g-PDMAEMA 共聚物颗粒在 0.15 N NaCl 水溶液和生理 pH 范围内稳定，这允许将它们用作靶向药物递送的载体。紫杉醇 (Ptx) 和 Na-CMC-g-PDMAEMA 共聚物之间的共轭是由于各组分官能团之间的疏水和静电相互作用；共聚物的特点是 Ptx 的负载和封装效率相对较高。还在 38 °C 的酸性和中性介质中研究了体外释放动力学。Korsmeyer-Peppas 动力学模型描述了共聚物偶联物中 Ptx 的释放过程，并受分子扩散的限制。