Purpose

Higher serum estradiol levels occur in women undergoing assisted reproductive technology (ART) owing to ovarian stimulation. Here, we investigated the association between maternal serum estradiol levels and the intellectual development of offspring conceived with ART.

Methods

A total of 204 singletons born after fresh embryo transfer were recruited for this cohort study. Among them, 102 children were born from mothers with high serum estradiol levels (> 12,000 pmol/L) on the day that human chorionic gonadotropin was administered. Another 102 children, matched by gestational age and age of the children, were recruited as controls from mothers with low serum estradiol (≤ 12,000 pmol/L). The Wechsler Preschool and Primary Scale of Intelligence was used to evaluate the intellectual development of the children.

Results

Children from mothers with higher serum estradiol levels scored lower in the verbal intelligence quotient (IQ) tests and verbal comprehension than children whose mothers had lower estradiol levels. The main difference between the two groups was in verbal subtests including information, vocabulary, and sorting. Partial correlation analysis revealed that the logarithm of maternal serum estradiol level negatively correlated with verbal IQ, performance IQ, and full scale IQ.

Conclusion

Our data demonstrate that a high maternal serum estradiol level may negatively associate the verbal ability of children conceived via ART.

中文翻译：

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在子宫内暴露于高血清雌二醇的ART所致儿童的口头表达能力下降。

目的

由于卵巢刺激，接受辅助生殖技术（ART）的妇女血清雌二醇水平较高。在这里，我们调查了孕妇血清雌二醇水平与ART设想的后代智力发育之间的关系。

方法

此队列研究共招募了204个在新鲜胚胎移植后出生的单身人士。其中，有102名儿童是在服用人绒毛膜促性腺激素的那天从血清雌二醇水平高（> 12,000 pmol / L）的母亲出生的。从血清雌二醇水平低（≤12,000 pmol / L）的母亲中招募了另外102名儿童，根据其胎龄和年龄进行了匹配。韦氏儿童学前教育和小学智力量表用于评估儿童的智力发展。

结果

母亲的血清雌二醇水平较高的孩子在言语智商（IQ）测试和口头理解方面的得分低于母亲的雌二醇水平较低的孩子。两组之间的主要区别在于语言子测验，包括信息，词汇和排序。偏相关分析显示，母亲血清雌二醇水平的对数与言语智商，表现智商和全智商呈负相关。

结论

我们的数据表明，孕妇血清雌二醇水平过高可能会对通过ART接受治疗的儿童的口头表达产生负面影响。