Data on the association between fibromyalgia syndrome (FMS) and psoriasis are scarce. We aimed to examine the association between FMS and psoriasis using a large-scale observational population-based study. This cross-sectional study analyzed data from a big computerized database to evaluate potential differences in the prevalence of psoriasis between patients with FMS and matched control subjects. The study included 18,598 patients with FMS and 36,985 controls. The prevalence of psoriasis was increased in patients with FMS as compared with control subjects (6.7% vs. 4.8%, respectively; OR, 1.4; 95% CI, 1.3–1.5; P < 0.001). This association was robust to multivariate analysis adjustment for sex, age, ancestry, socioeconomic status, and healthcare utilization (OR, 1.3; 95% CI, 1.2–1.4; P < 0.001). When compared with patients with only FMS, patients with a dual diagnosis of FMS and psoriasis presented with FMS at a significantly older age, had a higher mean BMI, and a higher frequency of smoking. To conclude, we found a significant association between FMS and psoriasis. More extensive cooperation between dermatologists and rheumatologists is suggested to enable early identification of their co-occurrence.

关于纤维肌痛综合征 (FMS) 与银屑病之间关联的数据很少。我们旨在使用大规模观察性人群研究来检查 FMS 与银屑病之间的关联。这项横断面研究分析了来自大型计算机数据库的数据，以评估 FMS 患者与匹配的对照受试者之间银屑病患病率的潜在差异。该研究包括 18,598 名 FMS 患者和 36,985 名对照组。与对照组相比，FMS 患者的银屑病患病率增加（分别为 6.7% 和 4.8%；OR，1.4；95% CI，1.3–1.5；P  < 0.001）。这种关联对于性别、年龄、血统、社会经济地位和医疗保健利用的多变量分析调整是稳健的（OR，1.3；95% CI，1.2-1.4；P < 0.001)。与仅患有 FMS 的患者相比，患有 FMS 和银屑病双重诊断的患者出现 FMS 的年龄显着更高，平均 BMI 更高，吸烟频率更高。总而言之，我们发现 FMS 与银屑病之间存在显着关联。建议皮肤科医生和风湿病学家之间进行更广泛的合作，以便及早识别它们的共同发生。