During aging, physiological and physical frailty occur, which is accompanied by a decline in adaptive and innate immunity, termed ‘immunosenescence’ characterized by marked changes in the composition, function, and competence of the human immune system. Moreover, the capabilities of the immune system to defend the human body against infections, to detect and destruct malignant or autoreactive cells decline, resulting in an increase in the susceptibility to infection, development of cancer, as well as autoimmune disorders. The study of age-related changes in immune function is an important area of investigation. In this review, the function of the immune system during aging, as well as the different ways to rejuvenate the aging immune system, is explored, as medical intervention, balanced nutrition, and a healthy life style will be discussed.

在衰老过程中，会出现生理和身体虚弱，伴随着适应性和先天免疫的下降，称为“免疫衰老”，其特征是人体免疫系统的组成、功能和能力发生显着变化。此外，免疫系统保护人体免受感染、检测和破坏恶性或自身反应细胞的能力下降，导致感染、癌症和自身免疫性疾病的易感性增加。与年龄相关的免疫功能变化的研究是一个重要的研究领域。本文探讨了免疫系统在衰老过程中的功能，以及恢复衰老免疫系统活力的不同方法，并讨论了医疗干预、均衡营养和健康的生活方式。