Chromatographic separation of the extracts of the Australian rainforest plant Ternstroemia cherryi led to the isolation of five undescribed barrigenol-like triterpenoids, ternstroenols A - E, from the fruits and three known ones from the leaves. Ternstroenols A - E represent a new form of structural diversity, being the first in its kind to incorporate a trans- 2, 4, 6- decatrienoyl moiety at C-22. The structures of the ternstroenols were assigned by detailed spectroscopic analysis, degradation and chemical derivatization. All compounds exhibited potent anti-inflammatory activity in LPS and IFN- γ activated RAW 264.7 macrophages, with IC50 values as low as 0.7 μM. Despite the remarkable potency, high levels of unwanted cell growth inhibition was also observed, which prompted their cytotoxic evaluation in U87/U251 human glioblastoma cell lines.

中文翻译：

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Ternstroenols A – E：来自澳大利亚雨林植物 Ternstroemia cherryi 的未描述的五环三萜

对澳大利亚热带雨林植物 Ternstroemia cherryi 的提取物进行色谱分离，从果实中分离出五种未描述的藤黄醇样三萜类化合物，即 ternstroenols A - E，从叶子中分离出三种已知的三萜。Ternstroenols A - E 代表了一种新形式的结构多样性，是同类中第一个在 C-22 处包含反式 2, 4, 6- 十三烯酰基部分的产品。通过详细的光谱分析、降解和化学衍生，确定了萜烯醇的结构。所有化合物在 LPS 和 IFN-γ 激活的 RAW 264.7 巨噬细胞中均表现出有效的抗炎活性，IC50 值低至 0.7 μM。尽管具有显着的效力，但也观察到了高水平的不需要的细胞生长抑制，这促使它们在 U87/U251 人胶质母细胞瘤细胞系中进行细胞毒性评估。