BACKGROUND The neuroinflammatory process is associated with the pathogenesis of many cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term vitamin D lack leads to over-activation of the reninangiotensin-aldosterone system (RAAS), one of the essential mechanisms of blood pressure regulation. PURPOSE OF REVIEW This review summarizes the latest studies carried out to evaluate the primary mechanisms underlying the neuroprotective effect of vitamin D and its receptors (VDR) in the central nervous system. Besides, the present article condenses the evidence supporting the link between vitamin D and the RAAS in hypertension and neuroinflammation. Highlights Standpoints: Vitamin D deficiency is highly prevalent in the world, and the rising prevalence of neuroinflammatory diseases and associated pathologies such as hypertension around the world justifies the urgent need of searching new and more effective therapeutic methods that could be related to RAAS modulation and vitamin D levels management.

中文翻译：

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维生素D-RAAS连接：心血管和神经炎症性疾病的综合观点。

背景技术神经炎性过程与许多心血管疾病，特别是高血压的发病机理有关。在这方面，维生素D的缺乏似乎增加了与神经炎症相关的心血管疾病的风险。长期缺乏维生素D会导致肾血管紧张素-醛固酮系统（RAAS）过度活化，这是血压调节的基本机制之一。综述的目的这篇综述总结了最新的研究，以评估维生素D及其受体（VDR）对中枢神经系统的神经保护作用的主要机制。此外，本文总结了支持维生素D与RAAS在高血压和神经炎症中联系的证据。重点观点：