Adipic dihydrazide and heparin were attached to ZnO quantum dots surface, and the ZnO-adipic dihydrazide-heparin nanocomplex was used as a drug delivery system to deliver paclitaxel for chemotherapy. The surface modification and the loading of paclitaxel were confirmed by Fourier transform infrared spectrum, featured by characteristic peaks from functional groups of adipic dihydrazide, heparin, and paclitaxel. The impacts of pH on the drug release were investigated, and the cytotoxicity studies were conducted with A549 cells. The pharmacokinetic study was conducted with male Wistar rats. Both in vitro and in vivo study indicated that ZnO-adipic dihydrazide-heparin-paclitaxel nanocomplex could deliver paclitaxel in a more controllable way, and it has the potential to be a high-efficiency drug delivery system for cancer treatment.

己二酸二酰肼和肝素附着在ZnO量子点表面，并且ZnO-己二酸二酰肼-肝素纳米复合物被用作药物输送系统来输送紫杉醇用于化疗。紫杉醇的表面修饰和负载量通过傅立叶变换红外光谱确定，其特征在于来自己二酸二酰肼，肝素和紫杉醇的官能团的特征峰。研究了pH对药物释放的影响，并对A549细胞进行了细胞毒性研究。用雄性Wistar大鼠进行了药代动力学研究。体内外研究均表明，ZnO-己二酸二酰肼-肝素-紫杉醇纳米复合物可以更可控的方式输送紫杉醇，具有成为治疗癌症的高效药物输送系统的潜力。