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Analysis of blood culture in a rat model of cecal ligation and puncture induced sepsis
Intensive Care Medicine Experimental Pub Date : 2020-06-05 , DOI: 10.1186/s40635-020-00310-6
Prabakar Vaittinada Ayar 1, 2, 3 , Hervé Jacquier 3, 4, 5 , Benjamin Deniau 2, 3, 6 , Feriel Azibani 2, 3 , Alexandre Mebazaa 2, 3, 6 , Alice Blet 2, 3, 6
Affiliation  

* Correspondence: pvaittinada@ gmail.com Emergency Department, Beaujon Hospital, AP-HP, 100, Boulevard du Général Leclerc, 92300 Clichy, France INSERM UMR-S942 MASCOTT, Paris, France Full list of author information is available at the end of the article To the Editor, Sepsis shows a high incidence and is associated with a high mortality [1, 2], and experimental studies are useful for a better understanding of sepsis and for identifying new therapies [3]. The cecal ligation and puncture (CLP) model is considered as the gold standard experiment for studying sepsis in animals. Recent guidelines recommend resuscitating animals after performing CLP including administration of fluid and chosen antimicrobials based on known pathogens. However, microbial identification is not a common practice in pre-clinical models of sepsis. The aims of this original study were:

中文翻译:

盲肠结扎穿刺致败血症大鼠模型血培养分析

* 通讯地址:pvaittinada@gmail.com 急诊科,Beaujon Hospital, AP-HP, 100, Boulevard du Général Leclerc, 92300 Clichy, France INSERM UMR-S942 MASCOTT, Paris, France文章 致编辑,脓毒症发病率高,死亡率高 [1, 2],实验研究有助于更好地了解脓毒症和确定新疗法 [3]。盲肠结扎和穿刺 (CLP) 模型被认为是研究动物败血症的金标准实验。最近的指南建议在执行 CLP 后对动物进行复苏,包括根据已知病原体给予液体和选择的抗菌剂。然而,微生物鉴定在脓毒症的临床前模型中并不常见。
更新日期:2020-06-05
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