Transient receptor potential melastatin 7 (TRPM7), along with the closely related TRPM6, are unique channels that have dual operations: cation permeability and kinase activity. In contrast to the limited tissue distribution of TRPM6, TRPM7 is widely expressed among tissues and is therefore implicated in a variety of cellular functions physiologically and pathophysiologically. The discovery of TRPM7's unique structure imparting dual ion channel and kinase activities shed light onto novel and peculiar biological functions, such as Mg2+ homeostasis, cellular Ca2+ flickering, and even intranuclear transcriptional regulation by a cleaved kinase domain translocated to nuclei. Interestingly, at a higher level TRPM7 participates in several biological processes in the nervous and cardiovascular systems, in which excitatory responses in neurons and cardiomyocytes are critical for their function. Here, we review the roles of TRPM7 in cells involved in the nervous and cardiovascular systems and discuss its potential as a future therapeutic target.

中文翻译：

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神经和心血管系统中的TRPM7通道。

瞬态受体电位褪黑素7（TRPM7）与紧密相关的TRPM6是独特的通道，具有双重功能：阳离子渗透性和激酶活性。与有限的TRPM6组织分布相反，TRPM7在组织中广泛表达，因此在生理和病理生理上与多种细胞功能有关。TRPM7独特结构的发现赋予了双离子通道和激酶活性，这为新型和特殊的生物学功能提供了亮点，例如Mg2 +稳态，细胞Ca2 +闪烁，甚至通过易位的激酶结构域转移到核中进行核内转录调控。有趣的是，TRPM7在较高水平上参与了神经系统和心血管系统的多个生物过程，其中神经元和心肌细胞的兴奋性反应对其功能至关重要。在这里，我们回顾了TRPM7在神经和心血管系统所涉及的细胞中的作用，并讨论了其作为未来治疗靶标的潜力。