Nanoparticles are widely used in cancer therapy because of their nanoscale, high surface ratio, multifunctionality and so on. With specific construction of nanoparticles, by choosing magnetic nanomaterials or citric acid-coated nanoparticle, scientists can kill tumor cells effectively and accurately, importantly reducing the side effects of conventional chemotherapy. Scientists not only have designed nanoparticles loaded with therapeutic drugs, but also those equipped with targeted molecules. These works have made nanoparticles multifunctional nanocarriers. As multifunctional nanocarriers, nanoparticles play an important role of drug delivery and normally, enabling drug delivery to tumor tissues is a difficult task. During the period of internal circulation, it is hard to maintain the stability of the nanocarriers not attached to normal cells or serum. With the application of stimulus-responsive nanomaterials, scientists have developed many nanocarriers with controllable drug release. These controllable drug delivery systems can quickly respond to microenvironmental changes (PH, enzyme, etc.) or external stimuli (photo, heat, magnetic or electric fields). Thus, to overcome the side effects of controllable drug delivery systems in vivo, in this article, we summarize the various kinds of stimulus-responsive nanocarriers for cancer therapy and discuss the possibilities and challenges in future application.

纳米粒子因其纳米级、高表面积比、多功能性等特点被广泛应用于癌症治疗。通过纳米粒子的特殊构造，通过选择磁性纳米材料或柠檬酸包覆的纳米粒子，科学家们可以有效准确地杀死肿瘤细胞，重要的是减少常规化疗的副作用。科学家们不仅设计了载有治疗药物的纳米粒子，还设计了装有靶向分子的纳米粒子。这些工作使纳米颗粒成为多功能纳米载体。作为多功能纳米载体，纳米颗粒在药物递送方面发挥着重要作用，通常情况下，将药物递送到肿瘤组织是一项艰巨的任务。内循环期间，没有附着在正常细胞或血清上的纳米载体很难保持稳定性。随着刺激响应纳米材料的应用，科学家们开发了许多具有可控药物释放的纳米载体。这些可控的给药系统可以快速响应微环境变化（PH、酶等）或外部刺激（光、热、磁场或电场）。因此，为了克服体内可控给药系统的副作用，在本文中，我们总结了用于癌症治疗的各种刺激响应纳米载体，并讨论了未来应用的可能性和挑战。这些可控的给药系统可以快速响应微环境变化（PH、酶等）或外部刺激（光、热、磁场或电场）。因此，为了克服体内可控给药系统的副作用，在本文中，我们总结了用于癌症治疗的各种刺激响应纳米载体，并讨论了未来应用的可能性和挑战。这些可控的给药系统可以快速响应微环境变化（PH、酶等）或外部刺激（光、热、磁场或电场）。因此，为了克服体内可控给药系统的副作用，在本文中，我们总结了用于癌症治疗的各种刺激响应纳米载体，并讨论了未来应用的可能性和挑战。