Abstract

This study aimed to investigate the role of lncRNA AK131850 in thoracic aortic aneurysm (TAA). We found that AK131850 was downregulated, while TGF-β1 was upregulated in aortic media specimen of thoracic aortic aneurysm (TAA) patients. In addition, AK131850 and TGF-β1 inversely correlated. Altered expression levels of AK131850 and TGF-β1 distinguished TAA patients from healthy controls. In human aortic smooth muscle cells (HAOSMC), AK131850 overexpression led to downregulated, while AK131850 siRNA silencing led to upregulated TGF-β1. AK131850 overexpression resulted in promoted, while siRNA silencing led to inhibited proliferation of HAOSMC. Therefore, AK131850 is downregulated in thoracic aortic aneurysm and negatively affects the levels of TGF-β1 in aortic smooth muscle cells.

摘要

本研究旨在探讨 lncRNA AK131850 在胸主动脉瘤 (TAA) 中的作用。我们发现在胸主动脉瘤 (TAA) 患者的主动脉中层标本中 AK131850 下调，而 TGF-β1 上调。此外，AK131850 与 TGF-β1 呈负相关。AK131850 和 TGF-β1 表达水平的改变将 TAA 患者与健康对照区分开来。在人主动脉平滑肌细胞 (HAOSMC) 中，AK131850 过表达导致下调，而 AK131850 siRNA 沉默导致 TGF-β1 上调。AK131850 过表达导致促进，而 siRNA 沉默导致抑制 HAOSMC 的增殖。因此，AK131850 在胸主动脉瘤中下调，并对主动脉平滑肌细胞中 TGF-β1 的水平产生负面影响。