A mini or partial arthroplasty may offer the advantages of reduced pain, shorter hospital stay, and increased range of motion, which are beneficial for the treatment of large-sized focal osteochondral defects. We aimed to evaluate the in vivo histologic response and function of our nonresorbable, composite structure implant, developed using polyetheretherketone (PEEK) and Ti6AI4V alloy, as a treatment for full-thickness osteochondral defects in the femoral head of the hip using a goat model. The gross and imaging appearance and histologic results were compared to those of a similar size cobalt-chromium-molybdenum (CoCrMo) alloy implant placed in a defect in the femoral head and evaluated up to 12 weeks. The X radiographs showed that there was no evidence of loosening of the implants for both the PEEK-Ti6AI4V and CoCrMo groups. Magnetic resonance imaging results showed no inflammatory signal findings in both PEEK-Ti6AI4V and CoCrMo implants. Macroscopically and histologica...

中文翻译：

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基于聚醚醚酮和 Ti6AI4V 的微型关节成形术植入物治疗髋关节股骨头局灶性骨软骨缺损的临床前评估。

微型或部分关节置换术可能具有减轻疼痛、缩短住院时间和增加活动范围的优点，这有利于治疗大尺寸局灶性骨软骨缺损。我们旨在评估我们的不可吸收复合结构植入物的体内组织学反应和功能，该植入物使用聚醚醚酮 (PEEK) 和 Ti6AI4V 合金开发，作为使用山羊模型治疗髋部股骨头全层骨软骨缺损的方法。将大体和影像学外观和组织学结果与放置在股骨头缺损中的类似尺寸的钴铬钼​​ (CoCrMo) 合金植入物进行比较，并进行了长达 12 周的评估。X 射线照片显示，对于 PEEK-Ti6AI4V 和 CoCrMo 组，没有植入物松动的迹象。磁共振成像结果显示 PEEK-Ti6AI4V 和 CoCrMo 植入物均未发现炎症信号。宏观和组织学...