The mesothelium when first described was thought to function purely as a non-adhesive surface to facilitate intracoelomic movement of organs. However, the mesothelium is now recognized as a dynamic cellular membrane with many important functions that maintain serosal integrity and homeostasis. For example, mesothelial cells interact with and help regulate the body's inflammatory and immune system following infection, injury, or malignancy. With recent advances in our understanding of checkpoint molecules and the advent of novel immunotherapy approaches, there has been an increase in the number of studies examining mesothelial and immune cell interaction, in particular the role of these interactions in malignant mesothelioma. This review will highlight some of the recent advances in our understanding of how mesothelial cells help regulate serosal immunity and how in a malignant environment, the immune system is hijacked to stimulate tumor growth. Ways to treat mesothelioma using immunotherapy approaches will also be discussed.

中文翻译：

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间皮细胞调节健康和疾病中的免疫反应：免疫治疗在恶性间皮瘤中的作用。

最初描述时，间皮被认为纯粹用作非粘性表面，以促进器官的腔内运动。然而，间皮现在被认为是一种动态细胞膜，具有许多维持浆膜完整性和体内平衡的重要功能。例如，间皮细胞在感染、损伤或恶性肿瘤后与身体的炎症和免疫系统相互作用并帮助调节它。随着我们对检查点分子理解的最新进展和新型免疫治疗方法的出现，检查间皮细胞和免疫细胞相互作用的研究数量有所增加，特别是这些相互作用在恶性间皮瘤中的作用。这篇综述将重点介绍我们在了解间皮细胞如何帮助调节浆膜免疫以及在恶性环境中如何劫持免疫系统以刺激肿瘤生长方面的一些最新进展。还将讨论使用免疫疗法治疗间皮瘤的方法。