Alzheimer's disease (AD) is progressive brain amyloidosis that damages brain regions associated with memory, thinking, behavioral and social skills. Neuropathologically, AD is characterized by intraneuronal hyperphosphorylated tau inclusions as neurofibrillary tangles (NFTs), and buildup of extracellular amyloid-beta (Aβ) peptide as senile plaques. Several biomarker tests capturing these pathologies have been developed. However, for the full clinical expression of the neurodegenerative events of AD, there exist other central molecular pathways. In terms of understanding the unidentified underlying processes for the progression and development of AD, a complete comprehension of the structure and composition of atypical aggregation of proteins is essential. Presently, to aid the prognosis, diagnosis, detection, and development of drug targets in AD, neuroproteomics is elected as one of the leading essential tools for the efficient exploratory discovery of prospective biomarker candidates estimated to play a crucial role. Therefore, the aim of this review is to present the role of neuroproteomics to analyze the complexity of AD.

中文翻译：

---

探索神经蛋白质组学在阿尔茨海默病中的潜力。

阿尔茨海默病 (AD) 是进行性脑淀粉样变性，会损害与记忆、思维、行为和社交技能相关的大脑区域。在神经病理学上，AD 的特征在于神经元内过度磷酸化的 tau 包裹体作为神经原纤维缠结 (NFT)，以及细胞外淀粉样蛋白 (Aβ) 肽的积累作为老年斑。已经开发了几种捕获这些病理的生物标志物测试。然而，对于 AD 神经退行性事件的完整临床表现，存在其他中心分子途径。在理解 AD 进展和发展的未识别潜在过程方面，完全理解蛋白质非典型聚集的结构和组成是必不可少的。目前，为了帮助预后、诊断、检测、和 AD 中药物靶点的开发，神经蛋白质组学被选为主要的重要工具之一，用于有效探索性发现预计将发挥关键作用的潜在生物标志物候选物。因此，本综述的目的是介绍神经蛋白质组学在分析 AD 复杂性方面的作用。